Online Archive accessible: 1977 - Aug 2009.
Psychotherapy meets neuroscience
A more focused future for psychotherapy research
Peter Fonagy
The ‘evidence base’ for my contribution to futurology is a set of integrative reviews of outcome studies of psychotherapy on which I have collaborated with a number of colleagues (Roth & Fonagy 1996; Fonagy et al, 2002a,2002b). This work is a pleasure, not so much because of the enlightenment that reading hundreds of papers provides, but rather because of the technical challenges that compiling material across broad fields invariably presents.
Looking into the future often initiates an appraisal of the past. At the risk of making implausibly broad generalisations, here are three observations concerning the limitations of the intensive research into psychotherapy outcomes over the past 3 decades. First, we know precious little about who is likely to benefit from what type of therapy; we know about some protocols that work, and can perhaps make generalisations about new protocols that are likely to be successful for particular diagnostic groups, but the literature is not very informative about clinically important choice points on pathways of care. Second, for many disorders a range of psychological approaches appear to be somewhat effective, but in most instances these therapies are made up of a collection of interventions of varying specificity. Further, the observed effects are rarely correlated with changes in putative mediating processes, making unequivocal causal attributions hazardous (e.g. Farmer et al, 2002). Third, psychotherapy researchers and practitioners, alike become attached to methods which they advocate in sometimes quite business-like ways, leading to rapid ‘guildification’ of even recently developed interventions (e.g. Linehan, 1993; Henggeler et al, 1994), not unlike the tragedy that befell psychoanalysis.
The psychotherapy research of the future will have to be more firmly rooted in developmental psychopathology. We increasingly appreciate that psychiatric disorders of adulthood are rooted in abnormalities already observable in childhood or adolescence (e.g. Kim-Cohen et al, 2003). There will be a merging of (developmental) psychopathology and psychotherapy research. It is likely that the elucidation of pathogenic mechanisms – essential for the development of effective and specific psychological interventions (Kazdin, 2003) – will only be achieved through developmental observations. The structured, manualised psychotherapy techniques of the future will be designed to specifically address empirically established developmental dysfunctions. Future psychotherapy trials will be increasingly seen as the only viable experimental tests of rival psychosocial aetiological models of personality (e.g. Hudson et al, 2002; Toth et al, 2002).
The value of well-targeted psychotherapy treatment outcome studies in modifying our model of psychopathology is well illustrated by early prevention programmes (see Howe et al, 2002). A report of a 20-year follow-up of an educational and physical enrichment programme showed that those who were demographically at high risk who underwent the programme manifested less schizotypal behaviour and lower levels of interpersonal deficits (Raine et al, 2003).
In addition to the ‘guildification’ and non-specificity of much current psychotherapy research, the measures of outcome used in many trials leave room for improvement. Most self-report measures in standard use are oriented towards symptom distress, and are of greatest relevance to trials of pharmacological products designed to address specific psychiatric symptoms. The virtual absence of user involvement in the devising of these measures has been a flaw in this approach. There is a significant risk that the evidence base we compile for psychotherapy will be almost uniquely shaped by professional priorities rather than by criteria important to users. Whereas the former have symptom distress at the core of all their systems, following the Ohio research (Crane-Ross et al, 2000; Roth Crane-Ross, 2002), we know that this may be by no means the most important concern of most service users, who worry far more about housing, employment and the presence of supportive companions. Most outcome measures are prone to bias and are potentially highly reactive (Sechrest et al, 1996), It is a striking and probably not unrelated fact that 70-80% of the variability in outcomes across studies can be predicted from the theoretical allegiance of the investigators (Luborsky et al, 1999).
Non-biased, non-subjective measures of outcome are urgently required. Neuroscience (particularly brain imaging) will deliver this sooner rather than later. Psychoneurobiology research is identifying neural correlates of complex subjective states (Adolphs, 2003), for example the experience of social exclusion (Eisenberger et al, 2003) or concern about the mental states of another person (Frith & Frith, 2003). There are indications that scanning techniques that allow the simultaneous imaging of two individuals interacting (Tomlin, Montague & King-Casas, Personal Communication, 2004) will be able to offer unbiased indicators of relationship quality as this changes as a consequence of psychological therapy.