www.psychspace.com心理学空间网Preventing the return of fear in humansusing reconsolidation update mechanisms
Daniela Schiller1,2,
Marie-H. Monfils1,3,
Candace M. Raio2,
David C. Johnson2,
Joseph E. LeDoux1&
Elizabeth A. Phelps1,2
Recent research on changing fears has examined targeting reconsolidation. During reconsolidation, stored information isrendered labile after being retrieved. Pharmacological manipulations at this stage result in an inability to retrieve thememories at later times, suggesting that they are erased or persistently inhibited. Unfortunately, the use of thesepharmacological manipulations in humans can be problematic. Here we introduce a non-invasive technique to target thereconsolidation of fear memories in humans.We provide evidence that old fear memories can be updated with non-fearfulinformation provided during the reconsolidation window. As a consequence, fear responses are no longer expressed, aneffect that lasted at least a year and was selective only to reactivated memories without affecting others. These findingsdemonstrate the adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories, and suggest anon-invasive technique that can be used safely in humans to prevent the return of fear.
http://www.neuroeconomics.nyu.edu/_files/Nature_2010_schiller_paper.pdfwww.psychspace.com心理学空间网
Daniela Schiller1,2,
Marie-H. Monfils1,3,
Candace M. Raio2,
David C. Johnson2,
Joseph E. LeDoux1&
Elizabeth A. Phelps1,2
Recent research on changing fears has examined targeting reconsolidation. During reconsolidation, stored information isrendered labile after being retrieved. Pharmacological manipulations at this stage result in an inability to retrieve thememories at later times, suggesting that they are erased or persistently inhibited. Unfortunately, the use of thesepharmacological manipulations in humans can be problematic. Here we introduce a non-invasive technique to target thereconsolidation of fear memories in humans.We provide evidence that old fear memories can be updated with non-fearfulinformation provided during the reconsolidation window. As a consequence, fear responses are no longer expressed, aneffect that lasted at least a year and was selective only to reactivated memories without affecting others. These findingsdemonstrate the adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories, and suggest anon-invasive technique that can be used safely in humans to prevent the return of fear.
http://www.neuroeconomics.nyu.edu/_files/Nature_2010_schiller_paper.pdfwww.psychspace.com心理学空间网
